| Vitamin A | All-trans retinoic acid; isotretinoin; retinaldehyde | Dermatology All-trans retinoic acid is used in the treatment of acute promyelocytic leukemia. Topical retinoids are used for acne and disorders of abnormal skin cell growth. | Retinoids activate nuclear retinoic acid receptors and regulate cell differentiation, proliferation, and gene expression. | Systemic retinoids can cause birth defects and require strict pregnancy precautions. Liver toxicity, lipid abnormalities, and mucocutaneous dryness may occur. |
| Vitamin D | Calcidiol; calcitriol; alfacalcidol | Bone and mineral disorders Used to prevent or treat vitamin D deficiency, nutritional rickets, osteomalacia, and selected cases of secondary hyperparathyroidism associated with chronic kidney disease. | Active vitamin D compounds increase intestinal calcium and phosphate absorption and help regulate parathyroid hormone activity and bone mineralization. | Excessive dosing may cause hypercalcemia, kidney stones, confusion, nausea, or cardiac rhythm abnormalities. Serum calcium and kidney function may require monitoring. |
| Vitamin K | Phytonadione; menaquinones | Coagulation Phytonadione is used to correct vitamin K deficiency and certain vitamin K–dependent coagulation abnormalities, including reversal of excessive anticoagulant effect under medical supervision. | Vitamin K is required for the hepatic activation of clotting factors II, VII, IX, and X, as well as proteins C and S. | It may reduce the effect of vitamin K–antagonist anticoagulants. The route and dose should be selected by a clinician because rapid administration can rarely cause serious reactions. |
| Vitamin B1 | Thiamine; thiamine pyrophosphate | Neurology and metabolism Used to treat or prevent thiamine deficiency, including Wernicke encephalopathy, beriberi, and deficiency associated with severe alcohol-use disorder or malnutrition. | Thiamine pyrophosphate serves as a coenzyme in carbohydrate metabolism and is essential for energy production and neuronal function. | In suspected Wernicke encephalopathy, thiamine is administered promptly, often before or together with glucose. Severe deficiency requires medical evaluation and appropriate parenteral therapy. |
| Vitamin B3 | Nicotinamide; nicotinic acid | Deficiency and lipid disorders Nicotinamide treats pellagra. Nicotinic acid has lipid-modifying activity, although its clinical use is limited by adverse effects and the availability of other lipid-lowering therapies. | Both forms contribute to NAD and NADP production, which support oxidation-reduction reactions and cellular energy metabolism. Nicotinic acid also affects lipid metabolism at pharmacologic doses. | High-dose nicotinic acid can cause flushing, liver injury, increased blood glucose, and increased uric acid. Therapeutic doses should be medically supervised. |
| Vitamin B6 | Pyridoxine; pyridoxal 5′-phosphate | Hematology and neurology Used to treat vitamin B6 deficiency and prevent or treat deficiency caused by certain medicines. It is also used in specific inherited disorders responsive to pyridoxine. | Pyridoxal 5′-phosphate is a coenzyme involved in amino-acid metabolism, neurotransmitter synthesis, and heme production. | Chronic excessive intake can cause sensory peripheral neuropathy. Dosage should be appropriate to the indication and duration of treatment. |
| Vitamin B9 | Folic acid; folinic acid; 5-methyltetrahydrofolate | Hematology and pregnancy care Used to prevent folate-deficiency megaloblastic anemia and reduce the risk of neural tube defects during pregnancy. Folinic acid is also used in selected chemotherapy-rescue and antifolate-treatment protocols. | Folate derivatives transfer one-carbon units needed for DNA synthesis, cell division, and red blood cell formation. | Folate can improve anemia caused by vitamin B12 deficiency while allowing neurological damage to progress. The cause of macrocytic anemia should be assessed before treatment. |
| Vitamin B12 | Cyanocobalamin; hydroxocobalamin; methylcobalamin | Blood and nervous system Used to treat vitamin B12 deficiency, pernicious anemia, and malabsorption-related deficiency, and to prevent neurological complications caused by prolonged deficiency. | Vitamin B12 supports DNA synthesis, red blood cell production, and myelin maintenance through methylation and odd-chain fatty-acid metabolism. | Treatment may require injections when absorption is impaired. Neurological symptoms can become irreversible if deficiency is left untreated for too long. |
| Vitamin C | Ascorbic acid; dehydroascorbic acid | Connective tissue and deficiency Used to prevent or treat scurvy and support collagen formation, wound healing, iron absorption, and antioxidant protection. | Ascorbate functions as a reducing agent and cofactor for enzymes involved in collagen synthesis and other metabolic pathways. | High oral doses may cause gastrointestinal discomfort and may increase kidney stone risk in susceptible individuals. It should not replace treatment for serious infections or chronic disease. |
| Vitamin E | Alpha-tocopherol; tocopheryl derivatives | Deficiency and antioxidant support Used to treat documented vitamin E deficiency, particularly when fat absorption is impaired. It is also used in selected nutritional-support settings. | Alpha-tocopherol protects cell membranes from lipid peroxidation and supports normal immune and neurological function. | High-dose supplementation may increase bleeding risk, especially with anticoagulant or antiplatelet medicines. Routine high-dose use is not established for preventing most chronic diseases. |